Karolis Variakojis is one of the most prominent conductors of the young Lithuanian generation. He is a guest conductor of the Lithuanian National Symphony Orchestra, the Lithuanian State Symphony Orchestra, the Orchestra of the Lithuanian National Opera and Ballet Theatre, the Lithuanian Chamber Orchestra, Kaunas City Symphony Orchestra, and the Contemporary Music Festival Gaida.
In 2019, the ensemble Synaesthesis, conducted by Variakojis, was awarded the title of Vilnius City Ensemble.
In 2020, Synaesthesis won the prestigious Ernst von Siemens Music Prize.